Phenotype Image Detail

Image

Caption

Scanning electron micrographs of glomeruli made at different magnifications, with the wild-type (+/+) mice shown in the left three panels and Ptpro^tm1Wig/Ptpro^tm1Wig (-/-) mice shown in the right three panels. The major processes seen in homozygous mutant mice were broader, wider, and less distinct than the narrower, more well-defined major processes seen in the wild type mice. The overall structure of the mutant podocytes is more amoeba-like compared with the octopus-like structure of the wild type (x3,000, top panels). At high power the foot processes of the wild type mice can be seen to be regular and fingerlike in appearance in contrast to the broader, shorter (more toelike) foot processes found in the mutant mice. (x10,000, bottom panels).

Copyright

This image is from Wharram BL, J Clin Invest 2000 Nov;106(10):1281-90 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:65903

Associated Alleles

Symbol	Name
Ptpro^tm1Wig	protein tyrosine phosphatase receptor type O; targeted mutation 1, Roger C Wiggins

Associated Genotypes

Allelic Composition	Genetic Background
Ptpro^tm1Wig/Ptpro^tm1Wig	involves: 129S1/Sv * 129X1/SvJ * C57BL/6