Phenotype Image Detail

Image

Caption

A-C: View of the palate with mandible removed from newborn mice. A: Wild type (WT) palate was completely closed with clear symmetrical rugae. B and C: Fgfr2^tm1.1Dsn/Fgfr2^tm1.1Dsn (Fgfr2b^-/-) and Fgf10^tm1Wss/Fgf10^tm1Wss (Fgfr10^-/-) mutants exhibited a similar wide cleft of the secondary palate, with a view into the nasal cavity (asterisks). D-L: E13 and E15 hematoxylin stained coronal sections through the oral cavity. G-I: Higher magnification views of D-F: By E13 the epithelium of WT mice had begun to thicken and stratify into a squamous pattern. That of both mutants was thin and lacked organization. Occasional patches of thicker epithelium did form, notably in Fgf10^tm1Wss/Fgf10^tm1Wss mice either at the medial epithelial edge (MEE) (I) or as outgrowths from the dorsum of the tongue (F, arrow). However, cells in these patches underwent apoptosis. K-L: Palatal shelves were positioned above the tongue but neither met nor fused. L: Epithelial fusion between the palatal shelf and mandible (arrow). C, cranial base; f, floor of the mouth; m, Meckel's cartilage; nc, nasal cavity; p, palatal shelf; t, tongue; tb, molar tooth bud. Scale Bars: A-C, 2um; D-L, 200um.

Copyright

This image is from Rice R, J Clin Invest 2004 Jun;113(12):1692-700 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:90909

Associated Alleles

Symbol	Name
Fgf10^tm1Wss	fibroblast growth factor 10; targeted mutation 1, W Scott Simonet
Fgfr2^tm1.1Dsn	fibroblast growth factor receptor 2; targeted mutation 1.1, Clive Dickson

Associated Genotypes

Allelic Composition	Genetic Background
Fgfr2^tm1.1Dsn/Fgfr2^tm1.1Dsn	involves: 129P2/OlaHsd
Fgf10^tm1Wss/Fgf10^tm1Wss	involves: 129X1/SvJ