Phenotype Image Detail

Image

Caption

A-H: Histological detection of iron content on cryostat sections of liver (A-D) and spleen (E-H) of wild type (WT, A,C,E and G) and Hjv^tm1Arbr/Hjv^tm1Arbr (Hjv^-/-, B,D,F and H) mice. Note uniform iron accumulation in the liver of 2.5-month-old mutant mice and absence thereof in the red pulp of the spleen. I: Quantitative determination of iron content (umol/g dry weight) in various organs of 2.5 month old wild type (white), Hjv^tm1Arbr/Hfe2⁺ (Hjv^+/-, gray), and Hjv^tm1Arbr/Hjv^tm1Arbr (black) mice (n=5 for each group). Asterisks indicate significant changes (P < 0.05) in homozygous mutant mice as compared with wild type littermates. J: Time course (P12-P300) of iron content (umol/g dry weight) determined in homozygous mutant mice (squares) compared with pooled wild type and heterozygous mice (triangles). Liver (green) and spleen (blue) are depicted in the graph. At least 3 animals per time point and genotype were included in the analysis. Asterisks indicate significant changes (P<0.05) in mutant mice as compared with pooled wild type and heterozygous littermates. Scale Bar: A and B, 270um; C and D, 45um; E and F, 1.2mm; G and H, 100um.

Copyright

This image is from Niederkofler V, J Clin Invest 2005 Aug;115(8):2180-6 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:100173

Associated Alleles

Symbol	Name
Hjv^tm1Arbr	hemojuvelin BMP co-receptor; targeted mutation 1, Silvia Arber

Associated Genotypes

Allelic Composition	Genetic Background
Hjv^tm1Arbr/Hjv^tm1Arbr	involves: 129S4/SvJae * 129X1/SvJ