Phenotype Image Detail

Image

Caption

A: Hematoxylin and eosin staining shows that in Akt1^tm1Hem/Akt1^tm1Hem mouse placenta, the major layers of decidua, spongiotrophoblast, and labyrinth were reduced, but the decrease of decidua was more significant that other layers. Magnification, x20. De, decidua. B, periodic acid Schiff's staining shows a marked reduction of glycogen-containing cells in the spongiotrophoblast in mutant placentae. Magnification, x20. C: Higher magnification of B, x40. Bracket indicates the glycogen-containing cells in the spongiotrophoblast. D-F: Structure of the labyrinth revealed by alkaline phosphatase staining. D, the outline of the labyrinth is clearly shown (blue color). Note that the vasculature is disordered in mutant 1. Magnification, x20. E, higher magnification of D, x40. Fetal erythrocytes are stained brown in the blood vessels. Note that in the mutant 1, fetal blood vessels were dilated, and the total blood vessel area was greatly reduced. Mutant 2 shows reduced and disordered vasculature. F, higher magnification (x100) of labyrinth.

Copyright

This image is from Yang ZZ, J Biol Chem 2003 Aug 22;278(34):32124-31 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:85181

Associated Alleles

Symbol	Name
Akt1^tm1Hem	thymoma viral proto-oncogene 1; targeted mutation 1, Brian A Hemmings

Associated Genotypes

Allelic Composition	Genetic Background
Akt1^tm1Hem/Akt1^tm1Hem	involves: 129P2/OlaHsd * C57BL/6