Phenotype Image Detail

Image

Caption

A and B: Representative Oil-Red-O-stained aortic lesions from 6 month old Apoe^tm1Unc/Apoe^tm1Unc (A) and Soat1^tm1Far/Soat1^tm1Far Apoe^tm1Unc/Apoe^tm1Unc (B) mice fed a chow diet. Note the pale appearance of the Soat1^tm1Far/Soat1^tm1Far Apoe^tm1Unc/Apoe^tm1Unc lesions due to a paucity of neutral lipids that stain with Oil-Red-O. C and D: Representative sections of plastic-embedded, osmium tetroxide-stained aortic lesions from Ldlr^tm1Her/Ldlr^tm1Her (C) and Soat1^tm1Far/Soat1^tm1Far Ldlr^tm1Her/Ldlr^tm1Her (D) mice fed an atherogenic diet for 2 months. Neutral lipid droplets (thin arrows) and numerous lucencies from cholesterol crystals (thick arrows) are apparent in the Ldlr^tm1Her/Ldlr^tm1Her lesion (C). Soat1^tm1Far/Soat1^tm1Far Ldlr^tm1Her/Ldlr^tm1Her lesions were devoid of osmium tetroxide staining and had fewer cholesterol cyrstals than Ldlr^tm1Her/Ldlr^tm1Her lesions.

Copyright

This image is from Accad M, J Clin Invest 2000 Mar;105(6):711-9 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:61147

Associated Alleles

Symbol	Name
Apoe^tm1Unc	apolipoprotein E; targeted mutation 1, University of North Carolina
Ldlr^tm1Her	low density lipoprotein receptor; targeted mutation 1, Joachim Herz
Soat1^tm1Far	sterol O-acyltransferase 1; targeted mutation 1, Bob Farese

Associated Genotypes

Allelic Composition	Genetic Background
Apoe^tm1Unc/Apoe^tm1Unc Soat1^tm1Far/Soat1^tm1Far	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
Ldlr^tm1Her/Ldlr^tm1Her Soat1^tm1Far/Soat1^tm1Far	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J