Phenotype Image Detail

Image

Caption

Ultrastructure of epidermis. Sections of normal (A,D and F) and Tgm1^tm1Kfyn/Tgm1^tm1Kfyn (B,C,E and G) mouse epidermis at 18.5 dpc. C in A, cornified cell; arrow in the inset of A, cell envelope; K in A, keratohyalin F-granule in the stratum granulosum; K in B, a swollen Keratohyalin F-granule; arrows in B and C, abnormal electron-dense aggregates adherent or close to the plasma membrane. (D-G) Section of stratum corneum labeled with anti-loricrin antibody and 10 nm gold. Arrowheads in D, cell envelope; arrows in E, abnormal electron-dense aggregates; arrowheads in E, cell membrane. (F and G) Sections digested with proteases. (x12,200 in A and B; x28,400 in the inset of A and in C; x19,500 in D-G. Bar, 0.8um in A and B; 0.34um in the inset of A and in C; 0.5um in D-G.)

Copyright

This image is from Matsuki M, Proc Natl Acad Sci U S A 1998 Feb 3;95(3):1044-9. Copyright 1998 National Academy of Sciences, U.S.A. J:45653

Associated Alleles

Symbol	Name
Tgm1^tm1Kfyn	transglutaminase 1, K polypeptide; targeted mutation 1, Kiyofumi Yamanishi

Associated Genotypes

Allelic Composition	Genetic Background
Tgm1^tm1Kfyn/Tgm1^tm1Kfyn	involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6