Phenotype Image Detail

Image

Caption

A: Wild type (Lum ^+/+ Fmod ^+/+, left) and Fmod^tm1Aol/Fmod^tm1Aol Lum^tm1Chak/Lum^tm1Chak (right) to demonstrate small body size and short stature. B: Gait abnormality in the double mutant mouse. Note abnormal positioning of the hind leg (arrow). C: Knee laxity measurements show significantly increased laxity in the double mutant mouse. Representative load-deflection curves are shown for one cycle during the knee laxity test. Joint laxity was defined by adding the tibial deflections in the anterior and posterior directions up to the point when the loading phase in each direction (indicated by arrow) reached a load magnitude of 0.5 newton from the inital load at zero defelction (dotted horizontal lines). Knee joint histology of transverse sections of femoral condyle of wild type (D, top panel) and double mutant mice (D, bottom panel). Note normal patella of wild type knees (arrows, top panel) located within the patella groove. In contrase, double mutant mice exhibited a medial misalignment of the patella (arrows, bottom panel). The distal femur exhibited a hypertrophic response, providing additional trabecular tissue to support the misaligned patella.

Copyright

This image is from Jepsen KJ, J Biol Chem 2002 Sep 20;277(38):35532-40 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:79115

Associated Alleles

Symbol	Name
Fmod^tm1Aol	fibromodulin; targeted mutation 1, Ake Oldberg
Lum^tm1Chak	lumican; targeted mutation 1, Shukti Chakravarti

Associated Genotypes

Allelic Composition	Genetic Background
Fmod^tm1Aol/Fmod^tm1Aol Lum^tm1Chak/Lum^tm1Chak	involves: 129S1/Sv * 129X1/SvJ * CD-1