Phenotype Image Detail

Image

Caption

Knee joint cross-sections stained with hematoxylin-chromotroph 2R. Serial sections through knees of 5 month old wild type (A), Lum^tm1Chak/Lum^tm1Chak (B), Fmod^tm1Aol/Fmod^tm1Aol (C) and Lum^tm1Chak/Lum^tm1Chak Fmod^tm1Aol/Fmod^tm1Aol (D). Double mutant mice show articular cartilage degeneration (asterisks).

Copyright

This image is from Jepsen KJ, J Biol Chem 2002 Sep 20;277(38):35532-40 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:79115

Associated Alleles

Symbol	Name
Fmod^tm1Aol	fibromodulin; targeted mutation 1, Ake Oldberg
Lum^tm1Chak	lumican; targeted mutation 1, Shukti Chakravarti

Associated Genotypes

Allelic Composition	Genetic Background
Fmod^tm1Aol/Fmod^tm1Aol Lum^tm1Chak/Lum^tm1Chak	involves: 129S1/Sv * 129X1/SvJ * CD-1