Phenotype Image Detail

Image

Caption

5 day old mice were injected with BrdUrd, and the labeling index was determined. A-C: Cell proliferation as measured by in vivo BrdUrd labeling index shows that cell proliferation is qualitatively unchanged in wild type and mutant lenses. A, wild type lens; B, Cryaa^tm1.1Ady/Cryaa⁺ lens; C, Cryaa^tm1.1Ady/Cryaa^tm1.1Ady lens. The labeling index was determined by dividing the number of BrdUrd positive cells with the total number of cells in each section. A total of three sections per lens and six lenses per genotype were analyzed. Note that the BrdUrd labeling index was 0.06+/- 0.01 in the wild type, 0.05 +/- 0.03 in heterozygous lenses, and 0.06 +/- 0.02 in homozygous lenses. D-F: TUNEL staining in mutant lens epithelial and fiber cells. D, wild type mouse lens; E, homozygous mouse lens; F, quantitative analysis of TUNEL staining in wild type, heterozygous and homozygous mouse lenses.

Copyright

This image is from Xi JH, J Biol Chem 2008 Feb 29;283(9):5801-14 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:132296

Associated Alleles

Symbol	Name
Cryaa^tm1.1Ady	crystallin, alpha A; targeted mutation 1.1, Usha P Andley

Associated Genotypes

Allelic Composition	Genetic Background
Cryaa^tm1.1Ady/Cryaa^+	involves: 129 * C57BL/6
Cryaa^tm1.1Ady/Cryaa^tm1.1Ady	involves: 129 * C57BL/6