Phenotype Image Detail

Image

Caption

Micrographs of transected lenses from a 6 month old wild type mouse (A), a 5 month old Crygs^Opj/Crygs^Opj mouse (B), and a 5 month old Crygs^Opj/Crygs⁺ mouse (C) showing epithelium (e), lens fibers (f) and nuclei (n) near the lens equator. Note in the homozygote, the gross disorganization of nuclei, swollen and vacuolated lens fibers (asterisks), irregularly shaped inclusion bodies with protein-like staining properties (arrows), and those with nucleic acid-like staining properties (arrowheads). Magnification: x206; calibration bar, 50um.

Copyright

This image is from Sinha D, J Biol Chem 2001 Mar 23;276(12):9308-15 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:68109

Associated Alleles

Symbol	Name
Crygs^Opj	crystallin, gamma S; opacity due to poor secondary fiber cell junctions

Associated Genotypes

Allelic Composition	Genetic Background
Crygs^Opj/Crygs^+	involves: 102 * C3H/He * T STOCK
Crygs^Opj/Crygs^Opj	involves: 102 * C3H/He * T STOCK