Phenotype Image Detail

Image

Caption

Hepatic lipid accumulation is observed in 5 month old male mice on a standard or high fat (HF) diet. A: Hematoxylin and eosin liver histology of wild type (WT) and Pparg^tm1Lja/Pparg⁺ (KI) mice. Both macrovesicular and microvesicular fat depositions are observed in mutant mice on a HF diet. PV, peripheral vein; CV, central vein. B: Hepatic TG (triglyceride) content for wild type and mutant mice. The mean +/- standard deviation is presented for the four groups of 5 month old mal mice; n = 4 or 5 for each group.

Copyright

This image is from Freedman BD, J Biol Chem 2005 Apr 29;280(17):17118-25 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:98786

Associated Alleles

Symbol	Name
Pparg^tm1Lja	peroxisome proliferator activated receptor gamma; targeted mutation 1, J Larry Jameson

Associated Genotypes

Allelic Composition	Genetic Background
Pparg^tm1Lja/Pparg^+	involves: 129S1/Sv * 129X1/SvJ