Phenotype Image Detail

Image

Caption

A: E10.5 Pip5k1c^Gt(XD096)Byg/Pip5k1c^Gt(XD096)Byg embryo (PIP5K1gamma -/-) has an extremely atrophic right ventricle and a ventricular septum that has failed to close (Left). As seen by distribution of Beta-gal in the Pip5k1c^Gt(XD096)Byg/Pip5k1c⁺ heart shown, only myocardial cells are predicted to express Pip5k1c mRNA (Right). B: Electron micrographs of wild type and homozygous cardiocytes. The red diamonds overlay the actin-rich sarcomeres, and the white arrows indicate the location of the fascia adherens. Loss of Pip5k1c leads to actin disorganization, and the loss of the normal association of actin cables with the fascia adherens. Scale bar: 1.0um. C: Immunogold-coupled anti-N-cadherin staining of heterozygous and homozygous cardiocytes demonstrated that cells lacking Pip5k1c do not have N-cadherin at the fascia adherens. Scale bar: 500nm.

Copyright

This image is from Wang Y, Proc Natl Acad Sci U S A 2007 Jul 10;104(28):11748-53. Copyright 2007 National Academy of Sciences, U.S.A. J:131432

Associated Alleles

Symbol	Name
Pip5k1c^Gt(XD096)Byg	phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma; gene trap XD096, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Pip5k1c^Gt(XD096)Byg/Pip5k1c^Gt(XD096)Byg	involves: 129P2/OlaHsd