Phenotype Image Detail

Image

Caption

Eng^tm1Mle/Eng⁺ (End +/-, Left) and Eng^tm1Mle/Eng^tm1Mle (End -/-, Right) embryos. Beta-gal expression driven by the Eng promoter was analyzed in whole heterozygous and homozygous embryos. At E9.0, embryos are of a similar size and their vasculature appears normal. The homozygous embryo shows an enlarged heart protruding forward (arrowhead). At E9.5, edematous pericardium (arrowhead) is observed in the homozygous embryo, which is growth-retarded compared with the heterozygote. At E10.5, the homozygous embryo is dead and is much smaller than the heterozygous embryo. Scale bar, 500um.

Copyright

This image is from Bourdeau A, J Clin Invest 1999 Nov;104(10):1343-51 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:58502

Associated Alleles

Symbol	Name
Eng^tm1Mle	endoglin; targeted mutation 1, Michelle Letarte

Associated Genotypes

Allelic Composition	Genetic Background
Eng^tm1Mle/Eng^tm1Mle	involves: 129P2/OlaHsd * C57BL/6