Phenotype Image Detail

Image

Caption

Transmission electron micrograph of 5 month old flexor digotorum longus (FDL) tendon collagen fibril morphology on the left in wild type (Lum ^+/+Fmod ^+/+, A), Lum^tm1Chak/Lum^tm1Chak (Lum^-/-Fmod^+/+, B), Fmod^tm1Aol/Fmod^tm1Aol (Lum^+/+Fmod^-/-, C) and Lum^tm1Chak/Lum^tm1Chak Fmod^tm1Aol/Fmod^tm1Aol (Lum^-/-Fmod^-/-, D) FDL tendons. Histograms on the right show the freguency of distribution of fibril diameter. Relative to the wild type, all three deficient genotypes have altered fibril structure, which is the least severe in the Lum^tm1Chak/Lum^tm1Chak tendons and most severe in the double homozygous tendons. All of the mutants show irregular fibril contours and abnormal association/fusion of adjacent fibrils (arrowheads). Except for Lum^tm1Chak/Lum^tm1Chak tendons, all other demonstrate a significant population of small diameter (20-59 nm) fibrils (arrows).

Copyright

This image is from Jepsen KJ, J Biol Chem 2002 Sep 20;277(38):35532-40 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:79115

Associated Alleles

Symbol	Name
Fmod^tm1Aol	fibromodulin; targeted mutation 1, Ake Oldberg
Lum^tm1Chak	lumican; targeted mutation 1, Shukti Chakravarti

Associated Genotypes

Allelic Composition	Genetic Background
Fmod^tm1Aol/Fmod^tm1Aol	involves: 129S1/Sv * 129X1/SvJ * CD-1
Fmod^tm1Aol/Fmod^tm1Aol Lum^tm1Chak/Lum^tm1Chak	involves: 129S1/Sv * 129X1/SvJ * CD-1