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Phenotype Image Detail
Image
Caption A and B: Plastic-embedded spinal cord sections from Hexbtm1Rlp/Hexbtm1Rlp (Hexb-/- GalNAcT+/+) (A) and Hexbtm1Rlp/Hexbtm1Rlp B4galnt1tm1Rlp/B4galnt1tm1Rlp (Hexb-/- GalNAcT-/-) (B) mice were stained with toluidine blue. Arrows indicate axonal degeneration. x270. C and D: Paraffin sections of cerebral cortex from single mutant (C) and double mutant (D) mice. Sections were stained with Luxol fast blue stain (LFB) and periodic acid-Schiff stain (PAS). Neuronal inclusions were stained blue (arrows) and perivascular macrophages were stained reddish-pink (arrowheads) x110. E and F: Electron micrographs of anterior horn neurons of spinal cord from single mutant (E) and double mutant (F) mice. x11,000. Note the differences in the contents of storage vacuoles (v).
Copyright This image is from Liu Y, J Clin Invest 1999 Feb;103(4):497-505 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:53080
Associated
Alleles
Symbol Name
B4galnt1tm1Rlp beta-1,4-N-acetyl-galactosaminyl transferase 1; targeted mutation 1, Richard L Proia
Hexbtm1Rlp hexosaminidase B; targeted mutation 1, Richard L Proia
Associated
Genotypes
Allelic Composition Genetic Background
Hexbtm1Rlp/Hexbtm1Rlp involves: 129S4/SvJae * C57BL/6
B4galnt1tm1Rlp/B4galnt1tm1Rlp
Hexbtm1Rlp/Hexbtm1Rlp
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory