Phenotype Image Detail

Image

Caption

A and B: Hematoxylin and eosin staining of the cerebellum from 8.5 month old Hexb^tm1Rlp/Hexb^tm1Rlp B4galnt1^tm1Rlp/B4galnt1^tm1Rlp mouse (Hexb-/-GalNAcT-/-) (A) and 8.5 month old B4galnt1^tm1Rlp/B4galnt1^tm1Rlp (Hexb+/+GalNAcT-/-) mouse (B). Arrows point out Purkinje cells. x110. C and D: Immunofluorescence staining of cerebellum with an anti-N-linked oligosaccharide antibody from 4.5 month old double mutant mouse (C) and Hexb^tm1Rlp/Hexb^tm1Rlp mouse (D). x130. Arrows point out Purkinje cells.

Copyright

This image is from Liu Y, J Clin Invest 1999 Feb;103(4):497-505 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:53080

Associated Alleles

Symbol	Name
B4galnt1^tm1Rlp	beta-1,4-N-acetyl-galactosaminyl transferase 1; targeted mutation 1, Richard L Proia
Hexb^tm1Rlp	hexosaminidase B; targeted mutation 1, Richard L Proia

Associated Genotypes

Allelic Composition	Genetic Background
Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129S4/SvJae * C57BL/6
B4galnt1^tm1Rlp/B4galnt1^tm1Rlp Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6