Phenotype Image Detail

Image

Caption

A-C: Histological sections of the heart outflow tract region of E14.5 fetuses show fully seperated aortic (AO) and pulmonary (PT) trunks in wild type (WT, A, arrows), whereas Aldh1a2^tm1Dll/Aldh1a2^tm1Ipc (neo/-, B) and Aldh1a2^tm1Dll/Aldh1a2^tm1Dll (neo/neo, C) mutants exhibit an unseptated (PTA) or partially septated (arrows) outflow tract. Hematoxylin and eosin staining. D and E: Wild type anatomy of the large arterial vessels, as observed after visualization of the arterial walls after alizarin red-alcian blue staining (D) or drawn from macroscopic examination (E) of newborn mice. F and G: Arterial patterns of two Aldh1a2^tm1Dll/Aldh1a2^tm1Ipc mutants (F, alizarin red-alcian blue staining; G, drawing from a newborn sepcimen). Both mutants show a right-sided aortic arch (RAA), such that the innominate artery (IA) gives rise to the LSA and carotid arteries, instead of the RSA and right common carotid (RCC). The descending aorta (DA) eventually reaches a normal left-sided thoracic position. Premature separation of the external and internal carotid arteries. (REC and RIC in F, LEC and LIC in G) is also seen. H and I: Arterial patterns of two Aldh1a2^tm1Dll/Aldh1a2^tm1Dll newborn mutants. The mouse in H lacked an innominate artery and its RSA, whereas its right internal (RIC) and external (REC) carotid arteries originated independently along the ascending aorta, and its left internal and external carotids (LIC and LEC) arose prematurely from the common carotid (LCC) at mid-cervical level (arrowhead). The mutant in I showed abnormally high cervical aortic arch and ectopic origins of the left carotid arteries (LIC and LEC) and RSA.

Copyright

This image is from Vermot J, Proc Natl Acad Sci U S A 2003 Feb 18;100(4):1763-8. Copyright 2003 National Academy of Sciences, U.S.A. J:81969

Associated Alleles

Symbol	Name
Aldh1a2^tm1Dll	aldehyde dehydrogenase family 1, subfamily A2; targeted mutation 1, Pascal Dolle

Associated Genotypes

Allelic Composition	Genetic Background
Aldh1a2^tm1Dll/Aldh1a2^tm1Dll	Not Specified
Aldh1a2^tm1Dll/Aldh1a2^tm1Ipc	involves: CD-1