Phenotype Image Detail

Image

Caption

A-C: Comparison of the laryngeal and tracheal cartilages of E18.5 wild type (WT, A) Aldh1a2^tm1Dll/Aldh1a2^tm1Ipc (neo/-, B) and Aldh1a2^tm1Dll/Aldh1a2^tm1Dll (neo/neo, C) mice. Alizarin red-alcian blue staining. D and E: Hyoid and thyroid carliages of wild type and Aldh1a2^tm1Dll/Aldh1a2^tm1Ipc mice, respectively. An ectopic cartilage connects these two elements in the mutant (bracket). F and G: Profile views of the cricoid cartilage and first tracheal ring of wild type and Aldh1a2^tm1Dll/Aldh1a2^tm1Ipc mice, respectively. The posterior aspect of this cartilage is abnormally segmented in the mutant (arrows). H and I: Coronal sections through the upper mediastinum of wild type and Aldh1a2^tm1Dll/Aldh1a2^tm1Ipc newborn mice, respectively, showing the absence of thymus (Tm) in the mutant (asterisks). At, atria (J and K) Sections through the lateral portions of the thyroid gland (Ty) of wild type and Aldh1a2^tm1Dll/Aldh1a2^tm1Ipc newborn mice, respectively, showing a lack of parathyroid glands (Pty) in the mutant; tetrachrome staining.

Copyright

This image is from Vermot J, Proc Natl Acad Sci U S A 2003 Feb 18;100(4):1763-8. Copyright 2003 National Academy of Sciences, U.S.A. J:81969

Associated Alleles

Symbol	Name
Aldh1a2^tm1Dll	aldehyde dehydrogenase family 1, subfamily A2; targeted mutation 1, Pascal Dolle
Aldh1a2^tm1Ipc	aldehyde dehydrogenase family 1, subfamily A2; targeted mutation 1, Pierre Chambon

Associated Genotypes

Allelic Composition	Genetic Background
Aldh1a2^tm1Dll/Aldh1a2^tm1Dll	Not Specified
Aldh1a2^tm1Dll/Aldh1a2^tm1Ipc	involves: CD-1