Phenotype Image Detail

Image

Caption

Right subclavian artery moprhology. C-E: Transverse sections through the hearts of E14.5 wild type (C), Vangl2^Lp/Vangl2^Lp (D), and Vangl1^Gt(XL802)Byg/Vangl1⁺ Vangl2^Lp/Vangl2⁺ (E) embryos. In wild type embryos (C), the right subclavian artery (arrows) is positioned laterally from trachea and esophagus. In homozygous (D) and double heterozygous (E) embryos, the right subclavian artery is positioned dorsal to the esophagus. F and G: Three-dimensional reconstruction of the arteries of E14.5 wild type (F) and double mutant hearts (G). Ao, aorta; DAo, dorsal aorta; E, esophagus; LV, left ventricle; PAA, pharyngeal arch artery; PV, pulmonary valve; RA, right atrium; rsca, right subclavian artery; RV, right ventricle; T, trachea; TH, thymic. Magnification x200.

Copyright

This image is from Torban E, Proc Natl Acad Sci U S A 2008 Mar 4;105(9):3449-54. Copyright 2008 National Academy of Sciences, U.S.A. J:132697

Associated Alleles

Symbol	Name
Vangl1^Gt(XL802)Byg	VANGL planar cell polarity 1; gene trap XL802, BayGenomics
Vangl2^Lp	VANGL planar cell polarity 2; loop tail

Associated Genotypes

Allelic Composition	Genetic Background
Vangl2^Lp/Vangl2^Lp	LPT/LeJ
Vangl1^Gt(XL802)Byg/Vangl1^+ Vangl2^Lp/Vangl2^+	involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ