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Caption | Representative radiographs (A, 3 weeks; B, 1 month; C, 3 months; D, 5 months; E, 12 months) and micro-CT (F) of upper first molar from wild type control (WT) and Dmp1tm1Mis/Dmp1tm1Mis (KO) mice show a overall reduction of mineralization and extracellular matrix (ECM) thickness of teeth. At 3 weeks, the mutant molar starts to show a reduction in root dentin thickness and mineral density, compared with the control molar (A, arrows). As the age increases, the reduction in muant dentin thickness is more dramatic and accompanied with enlarged pulp chambers and root canals in mutant mice (stars). | ||||
Copyright | This image is from Ye L, J Biol Chem 2004 Apr 30;279(18):19141-8 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:89498 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/15/2024 MGI 6.24 |
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