Phenotype Image Detail

Image

Caption

Representative radiographs (A, 3 weeks; B, 1 month; C, 3 months; D, 5 months; E, 12 months) and micro-CT (F) of upper first molar from wild type control (WT) and Dmp1^tm1Mis/Dmp1^tm1Mis (KO) mice show a overall reduction of mineralization and extracellular matrix (ECM) thickness of teeth. At 3 weeks, the mutant molar starts to show a reduction in root dentin thickness and mineral density, compared with the control molar (A, arrows). As the age increases, the reduction in muant dentin thickness is more dramatic and accompanied with enlarged pulp chambers and root canals in mutant mice (stars).

Copyright

This image is from Ye L, J Biol Chem 2004 Apr 30;279(18):19141-8 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:89498

Associated Alleles

Symbol	Name
Dmp1^tm1Mis	dentin matrix protein 1; targeted mutation 1, Yuji Mishina

Associated Genotypes

Allelic Composition	Genetic Background
Dmp1^tm1Mis/Dmp1^tm1Mis	involves: 129S7/SvEvBrd * C57BL/6