Phenotype Image Detail

Image

Caption

Scanning electron microscopy (SE) images of cross-sections (A, left) and longitudinal sections (A, right) from fractured 3 month wild type (WT) first molar (A and B) shows the normal structure of dentin; dentin tubule (DT), peritubular dentin (*), and intertubular dentin (clubsuit). Representative backscattered scanning electron microscopy images in both cross-section (B) and sagittal section (C) reveal a dramatic decrease in mineralization and a striking change in dentin matrix structure in 3 month old Dmp1^tm1Mis/Dmp1^tm1Mis mice (KO, stars) compared with the wild type mice. A further enlarged scanning electron microscopy image of a wall of the mutant peritubular area shows that matrix is poorly organized with increased spaces (arrow), suggesting a critical role of Dmp1 in control of dentin matrix morphology.

Copyright

This image is from Ye L, J Biol Chem 2004 Apr 30;279(18):19141-8 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:89498

Associated Alleles

Symbol	Name
Dmp1^tm1Mis	dentin matrix protein 1; targeted mutation 1, Yuji Mishina

Associated Genotypes

Allelic Composition	Genetic Background
Dmp1^tm1Mis/Dmp1^tm1Mis	involves: 129S7/SvEvBrd * C57BL/6