Phenotype Image Detail

Image

Caption

Predentin (pd), the newly formed nonmineralized matrix, matures into a mineralized dentin (d) during development. Representative hematoxylin and eosin stained sections of molars (A, 1 month, lower first molar; B, 12 months, upper first molar) and incisors (C, 3 months) show an extended predentin (red layer in newly formed matrix; light pink layer in adult mice) and a reduced dentin in Dmp1^tm1Mis/Dmp1^tm1Mis (KO) mice compared with the wild type (WT) mice, suggesting that Dmp1 is required for maturation of predentin into dentin. Note that the enamel layer is thinner in the muant mice, indicating that Dmp1 may play a role in normal amelogenesis (C). Am, ameloblasts; Od, odontoblasts; e, enamel.

Copyright

This image is from Ye L, J Biol Chem 2004 Apr 30;279(18):19141-8 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:89498

Associated Alleles

Symbol	Name
Dmp1^tm1Mis	dentin matrix protein 1; targeted mutation 1, Yuji Mishina

Associated Genotypes

Allelic Composition	Genetic Background
Dmp1^tm1Mis/Dmp1^tm1Mis	involves: 129S7/SvEvBrd * C57BL/6