Phenotype Image Detail

Image

Caption

Tooth abnormalities in 1 year old Dspp^tm1Kul/Dspp^tm1Kul mice. Extracted first molars from wild type (+/+, A) and homozygous mutant (-/-, B) mice, showing enlarged pulp cavity (*) by microradiography. Similarly, decreased mineral density was observed in the incisors (arrow) of the mutant mice (D). Prominent globular mineralized zones (arrow) in mutant incisors at the incisal end are shown as insets in D. Molars of mutant mice (F-H) show discoloration (arrow) and severe attrition, leading to the complete disappearance of tooth crown (dotted circle). Frontal sections of wild type (I) and mutant (J) skulls showing the distribution of calcium staining, abnormal molar pulp cavity and resorption of the bone surrounding the teeth (*). ab, alveolar bone; to, tongue; in, incisors; m1, molar 1; m2, molar 2; m3, molar 3; mo, molars.

Copyright

This image is from Sreenath T, J Biol Chem 2003 Jul 4;278(27):24874-80 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:84378

Associated Alleles

Symbol	Name
Dspp^tm1Kul	dentin sialophosphoprotein; targeted mutation 1, Ashok B Kulkarni

Associated Genotypes

Allelic Composition	Genetic Background
Dspp^tm1Kul/Dspp^tm1Kul	involves: 129/Sv * C57BL/6