Phenotype Image Detail

Image

Caption

Scanning, backscatter, and transmission electron microscopy analyses of the molars from wild type (+/+, A,C,E,G,I,K) and Dspp^tm1Kul/Dspp^tm1Kul (-/-, B,D,F,H,J,L) teeth showing enlarged predentin (B) and irregular mineralization front (D, white arrows), which often appears as pits (*) because of lack of coalescence of calcospherites, the void spaces in the dentin (*). Irregular dentinal tubules and scalloped dentin (void spaces as indicated by *) are prominent in the mutant teeth (F). G and H: Backscatter scanning electron microscopy showing lack of coalescence of calcospherites in teh dentin region with increasing number of void spaces (*) in the mutant mice (H). I and J: Higher magnification of the predentin region showing a lack of organized network in the tubular and inter-tubular regions in the mutant teeth (J and inset). K and L: Transmission electron microscopy analysis of decalcified teeth from wild type (K) and mutant (L) mice shows no obvious differences in the (arrows) organization of collagen fibrils/bundles (arrow). de, dentin; en, enamel; p, pulp; pd, predentin; dt, dentinal tubules.

Copyright

This image is from Sreenath T, J Biol Chem 2003 Jul 4;278(27):24874-80 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:84378

Associated Alleles

Symbol	Name
Dspp^tm1Kul	dentin sialophosphoprotein; targeted mutation 1, Ashok B Kulkarni

Associated Genotypes

Allelic Composition	Genetic Background
Dspp^tm1Kul/Dspp^tm1Kul	involves: 129/Sv * C57BL/6