Phenotype Image Detail

Image

Caption

General histology and presence of glycosamaminoglycans (GAGs) in the widened predentin. Dspp^tm1Kul/Dspp^tm1Kul molars (B) show widened predentin (*) and irregular mineralization (arrow) with globular dentin in the predentin (arrowheads). C-F: Higher magnifications of wild type (+/+, C and E) and mutant (-/-, D and F) molars (C and D) and incisors (E and F) showing widened predentin. G-J: Frozen tooth sections from 6 day old wild type (G and H) and mutant (I and J) mice were stained for GAG containing proteoglycans with Alcian blue before (G and I) and after (H and J) chondroitinase ABC treatment. de, dentin; p, pulp; pd, predentin.

Copyright

This image is from Sreenath T, J Biol Chem 2003 Jul 4;278(27):24874-80 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:84378

Associated Alleles

Symbol	Name
Dspp^tm1Kul	dentin sialophosphoprotein; targeted mutation 1, Ashok B Kulkarni

Associated Genotypes

Allelic Composition	Genetic Background
Dspp^tm1Kul/Dspp^tm1Kul	involves: 129/Sv * C57BL/6