Phenotype Image Detail

Image

Caption

Enamel prism pattern of fractured incisors from a wild type (A), Mmp20^tm1Jdb/Mmp20⁺ (B) and Mmp20^tm1Jdb/Mmp20^tm1Jdb (C) mouse. The enamel thickness is ~120um in the wild type and heterozygous but is approximately only 70um in the homozygous mouse. The typical decussating inner enamel rod pattern can be observed in the wild type and heterozygous but is absent in the enamel from the homozygous mouse. Note the enamel from the homozygous mouse did not fracture in the same plane as the dentin (De), indicating a faulty dentin/enamel junction.

Copyright

This image is from Caterina JJ, J Biol Chem 2002 Dec 20;277(51):49598-604 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:80925

Associated Alleles

Symbol	Name
Mmp20^tm1Jdb	matrix metallopeptidase 20 (enamelysin); targeted mutation 1, John D Bartlett

Associated Genotypes

Allelic Composition	Genetic Background
Mmp20^tm1Jdb/Mmp20^tm1Jdb	involves: 129P2/OlaHsd * C57BL/6