Phenotype Image Detail

Image

Caption

A: Histology of Sp6^tm1Yoya/Sp6⁺ (+/-, panels A-D) and Sp6^tm1Yoya/Sp6^tm1Yoya (-/-, panels E-H) molars. (Panels A,B,E and F, frontal sections, x40; panels C and G, x20; panels D and H, x10). Arrows, multiple branching, B: Histology of heterozygous (A-E) and homozygous (F-J). Panels C,D,E,H,I and J, frontal sections; panels A,B,F and G, sagittal sections. panels A,C,F, and H, x20; panels B,D,G,and I, x10; panels E and J, x40 (enlarged the boxed areas in panels D and I). de, dental epithelium; dm, dental mesenchyme; ode, outer dental epithelial cells; ide, inner dental epithelial cells; am, ameloblasts; cl, cervical loop; dn, dentin; en, enamel; em, enamel matrix; od, odontoblasts; den, dentin. Labium (la), oral cavity (OC), anterior (ant), and posterior (pos) indicate anatomical positions. The asterisk indicates dental lamina. Note: The enamel layer was detached from the dentin layer during sample preparation in control molars. (A, panels C and D) and incisors (B, panels D and E).

Copyright

This image is from Nakamura T, J Biol Chem 2008 Feb 22;283(8):4825-33 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:132157

Associated Alleles

Symbol	Name
Sp6^tm1Yoya	trans-acting transcription factor 6; targeted mutation 1, Yoshihiko Yamada

Associated Genotypes

Allelic Composition	Genetic Background
Sp6^tm1Yoya/Sp6^tm1Yoya	B6.129-Sp6^tm1Yoya