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Phenotype Image Detail
Image
Caption Top: Illustrative examples of wild type (WT) and Fbn1tm3Rmz/Fbn1tm3Rmz Fbn2tm1Rmz/Fbn2tm1Rmz (Fbn1-/- Fbn2-/-) embryos at E14.5. Bottom: Weigert-stained cross-sections of ascending aortas from the embryos shown above as well as from an additional double mutant embryo and a Fbn1tm3Rmz/Fbn1+ Fbn2tm1Rmz/Fbn2tm1Rmz (Fbn1+/-;Fbn2-/-) embryo documenting poor organization of the vessel wall in the double mutant samples. Scale bar, 50um.
Copyright This image is from Carta L, J Biol Chem 2006 Mar 24;281(12):8016-23 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:110586
Associated
Alleles
Symbol Name
Fbn1tm3Rmz fibrillin 1; targeted mutation 3, Francesco Ramirez
Fbn2tm1Rmz fibrillin 2; targeted mutation 1, Francesco Ramirez
Associated
Genotypes
Allelic Composition Genetic Background
Fbn1tm3Rmz/Fbn1tm3Rmz
Fbn2tm1Rmz/Fbn2tm1Rmz 		involves: 129
Fbn1tm3Rmz/Fbn1+
Fbn2tm1Rmz/Fbn2tm1Rmz 		involves: 129
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory