Phenotype Image Detail

Image

Caption

A and B: Photograph of the hind paws of 6 month old Prg4^tm1Mawa/Prg4^tm1Mawa (-/-, A) and wild type (+/+, B) mice. Note the curved digits in the mutant mouse and the swelling at the ankle joint. C and D: Radiograph of the ankle joint of 9 month old wild type and mutant mice respectively. The structures corresponding to the tibia (t) and talus (ta) are indicated. Note the calcification of structures adjacent to the ankle (white arrows). E: Lateral knee x-ray of a 4 month old wild type mouse. The structures corresponding to the patella (p), femoral condyle (f), tibial plateau (t), and fibula (fib) are indicated. F: Lateral knee x-ray of a 4 month old mutant mouse. Note the increased joint space between the patella and femur (arrowheads) and osteopenia of the patella, femoral condyles, and tibial plateau. G: Shoulder x-ray of a 4 month old wild type mouse. The structures corresponding to the humeral head (h), glenoid fossa of the scapula (s), and lateral portion of the clavicle (c) are indicated. H: Shoulder x-ray of a 4 month old mutant mouse. Note the increased joint space between the humerus and scapula (arrowheads) and the osteopenia of the humeral head.

Copyright

This image is from Rhee DK, J Clin Invest 2005 Mar;115(3):622-31 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:96756

Associated Alleles

Symbol	Name
Prg4^tm1Mawa	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein); targeted mutation 1, Matthew Warman

Associated Genotypes

Allelic Composition	Genetic Background
Prg4^tm1Mawa/Prg4^tm1Mawa	involves: 129S1/Sv * 129X1/SvJ