Phenotype Image Detail

Image

Caption

Histologic changes in the articular cartilage and synovium of Prg4^tm1Mawa/Prg4^tm1Mawa mice. Hematoxylin and eosin stained sagittal section through the tibia of a 7 day old Prg4^tm1Mawa/Prg4⁺ (+/-, A) and Prg4^tm1Mawa/Prg4^tm1Mawa (-/-, D) mice, 2 month old heterozygous (B) and homozygous (E) mice, and 9 month old heterozygous (C) and homozygous (F) mice (magnification in A-F, x400). Note that flattened superficial zone chondrocytes are present in both the heterozygous and homozygous cartilage of the 7 day old mice (arrows, A and D). Flattened superficial zone chondrocytes are present in both the 2 month old and 9 month old homozygous mice (E and F). Also note the presence of a thick layer of weakly stained material at the cartilage surface (bracket, E). G-L: Hematoxylin and eosin stained section of knee synovium from 15 day old wild type (G) and homozygous (H) mice (magnification, x400), 2 month old heterozygous (I) and homozygous (J) mice (magnification , x400), and 6 month old heterozygous (K) and homozygous (L) mice (magnification, x200). Note the progressive hyperplasia and thickening (brackets) of the intimal and subintimal layers in the homozyous mice (H,J and L).

Copyright

This image is from Rhee DK, J Clin Invest 2005 Mar;115(3):622-31 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:96756

Associated Alleles

Symbol	Name
Prg4^tm1Mawa	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein); targeted mutation 1, Matthew Warman

Associated Genotypes

Allelic Composition	Genetic Background
Prg4^tm1Mawa/Prg4^tm1Mawa	involves: 129S1/Sv * 129X1/SvJ