Phenotype Image Detail

Image

Caption

Ultrastructure of hypertrophic chondrocytes and territorial matrix. A and C: The hypertrophic chondrocyte in a normal (+/+) mouse femur has low organelle density. The septa are homogeneously filled with fibrillar collagen (arrows) and calcified material (c). B and D: The hypertrophic chondrocyte in a Hspg2^tm1Ref/Hspg2^tm1Ref (-/-) femur displays increased density of organelles, and the cytosol is highly enriched with free ribosomes and polysomes (arrowheads). The adjacent pericellular matrix compartment is filled with fibrillar collagen but lacks calcification. E and F: The territorial zone in normal cartilage shows random distribution of collagen fibrils. The collagen fibrils are of uniform diameter and length (E). The territorial zone in mutants lacks a well organized collagen fibrillar network. The collagen fibrils are shorter in length, lower in contrast and the density is reduced. Abbreviations: P, plasma membrane; N, cell nucleus; C, calcification. Bars: A and B, 5um; C-F, 0.5um.

Copyright

This image is from Costell M, J Cell Biol 1999 Nov 29;147(5):1109-22, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:58700

Associated Alleles

Symbol	Name
Hspg2^tm1Ref	perlecan (heparan sulfate proteoglycan 2); targeted mutation 1, Reinhard Fassler

Associated Genotypes

Allelic Composition	Genetic Background
Hspg2^tm1Ref/Hspg2^tm1Ref	involves: 129S1/Sv * 129X1/SvJ