Phenotype Image Detail

Image

Caption

Col5a1^tm1Rjw/Col5a1^tm1Rjw (col5a1-/-, A) and Col5a1^tm1Rjw/Col5a1⁺ (col5a1+/-, B) embryos are approximately the same size at day 10.5, but more blood is apparent in the heterozygous embryo. In the yolk sacs of day 10.5 embryos, the blood-filled vessels are evident in the heterozygotes (D) but not in the homozygotes (C). Pooled blood is observed in the homozygous yolk sac.

Copyright

This image is from Wenstrup RJ, J Biol Chem 2004 Dec 17;279(51):53331-7 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:113133

Associated Alleles

Symbol	Name
Col5a1^tm1Rjw	collagen, type V, alpha 1; targeted mutation 1, Richard J Wenstrup

Associated Genotypes

Allelic Composition	Genetic Background
Col5a1^tm1Rjw/Col5a1^tm1Rjw	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)