Phenotype Image Detail

Image

Caption

Electron micrographs of dermal tissues. A and C: In the wild type embryos at E10, large numbers of small diameter fibrils are deposited homgeneously beneath the ectoderm (E) basement membrane (arrowhead) and in the predermal mesenchyme between mesenchyme (M) cells and collagen fibrils (small arrows). B and D: In the Col5a1^tm1Rjw/Col5a1^tm1Rjw embryos at E10, no fibrils are deposited in the predermal mesenchyme (D), and only a few abnormally large fibrils are found associated with the ectodermal basement membrane (C). Scale bar: 300nm.

Copyright

This image is from Wenstrup RJ, J Biol Chem 2004 Dec 17;279(51):53331-7 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:113133

Associated Alleles

Symbol	Name
Col5a1^tm1Rjw	collagen, type V, alpha 1; targeted mutation 1, Richard J Wenstrup

Associated Genotypes

Allelic Composition	Genetic Background
Col5a1^tm1Rjw/Col5a1^tm1Rjw	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)