Phenotype Image Detail

Image

Caption

Electron micrographs of collagen fibril architecture in wild type and Col5a1^tm1Rjw/Col5a1^tm1Rjw embryos. The collagen fibrils assembled by the Col5a1^tm1Rjw/Col5a1^tm1Rjw (B) embryos are structurally abnormal. The wild type embryos (A) assemble large members of small diameter collagen fibrils with circular profiles in the space subjacent to the ectodermal basement membrane. In contrast, the mutant embryos assemble far fewer fibrils. These fibrils have abnormally large diameters. The few fibrils assembled by the mutant embryos have very irregular cross-sectional profiles (B inset) compared with the small, cylindrical profile seen in the wild type embryos (A, inset). Scale bar: 100nm.

Copyright

This image is from Wenstrup RJ, J Biol Chem 2004 Dec 17;279(51):53331-7 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:113133

Associated Alleles

Symbol	Name
Col5a1^tm1Rjw	collagen, type V, alpha 1; targeted mutation 1, Richard J Wenstrup

Associated Genotypes

Allelic Composition	Genetic Background
Col5a1^tm1Rjw/Col5a1^tm1Rjw	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)