Phenotype Image Detail

Image

Caption

Transmission electron micrographs of deep dermis from 12 week old mice showing abnormal collagen fibrils in Col5a1^tm1Rjw/Col5a1⁺. At postnatal week 12, the dermis of wild type mice has a single population of cylindrical collagen fibrils seen in cross-section (A) and longitudinally (B) (small arrows). The Col5a1^tm1Rjw/Col5a1⁺ have two intermixed fibril populations within the dermis (C and D). The first is a population of cylindrical fibrils that is comparable with those seen in the wild type dermis but larger in diameter (small arrows). The second population is composed of very large, heterogeneous fibrils with very irregular fibril contours (*) in cross-section (C). In the longitudinal section (D), the fibril surfaces are irregular, and the diameter is inconsistent along the fibril length. Scale bar: 300nm.

Copyright

This image is from Wenstrup RJ, J Biol Chem 2004 Dec 17;279(51):53331-7 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:113133

Associated Alleles

Symbol	Name
Col5a1^tm1Rjw	collagen, type V, alpha 1; targeted mutation 1, Richard J Wenstrup

Associated Genotypes

Allelic Composition	Genetic Background
Col5a1^tm1Rjw/Col5a1^+	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)