Phenotype Image Detail

Image

Caption

Transmission electron micrographs of fibrils in cross-section (A,C,E and G) and longitudinal section (B,D,F and H) from deep dermis of postnatal day 10 (A-D) and 20 week (E-H) dermis. The Col5a1^tm1Rjw/Col5a1⁺ (+/-) dermis contains roughly cylindrical fibrils (arrowheads) and abnormal fibrils (*) in developing (P10) and mature (20 week) dermis. The two fibril populations interact (small arrows) and disrupt the process of lateral/linear fibril growth. The resulting defects are more severe in the mature dermis relative to immature dermis where fibril growth is beginning.

Copyright

This image is from Wenstrup RJ, J Biol Chem 2006 May 5;281(18):12888-95 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:112728

Associated Alleles

Symbol	Name
Col5a1^tm1Rjw	collagen, type V, alpha 1; targeted mutation 1, Richard J Wenstrup

Associated Genotypes

Allelic Composition	Genetic Background
Col5a1^tm1Rjw/Col5a1^+	involves: 129S6/SvEvTac * C57BL/6