Phenotype Image Detail

Image

Caption

The Col5a1^tm1Rjw/Col5a1⁺ dermis contains a population of structurally aberrant collagen fibrils throughout development. Transmission electron micrographs from the deep dermis of the subscapular region from postnatal day 10, 6 week, and 20 week Col5a1^tm1Rjw/Col5a1⁺ (+/-, A-C) and wild type (+/+, D-F) mice. The wild type dermis contains a single population of fibrils roughly circular in profile. In contrast, the heterozygous mice contain two populations of fibrils. One is comparable with the circular profiles in the wild type dermis (open arrowheads), whereas the other consists of very large and structurally aberrant fibrils (*).

Copyright

This image is from Wenstrup RJ, J Biol Chem 2006 May 5;281(18):12888-95 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:112728

Associated Alleles

Symbol	Name
Col5a1^tm1Rjw	collagen, type V, alpha 1; targeted mutation 1, Richard J Wenstrup

Associated Genotypes

Allelic Composition	Genetic Background
Col5a1^tm1Rjw/Col5a1^+	involves: 129S6/SvEvTac * C57BL/6