Phenotype Image Detail

Image

Caption

A and B: Diaminobenzidine-catalase cytochemistry of wild type (A) and Pex2^tm1Plf/Pex2^tm1Plf (B) liver. Numerous dark staining peroxisomes are only identified in the wild type liver (arrows). Inset in A show characteristic morphology of rodent peroxisomes with a curvilinear, electron-dense core. C: Light microscopic examination of adrenal gland from a mutant mouse showing numerous clear clefts (arrows) consistent with lipid inclusions. Hematoxylin and eosin stain. D-F: Electron microscopic examination of adrenal gland from mutant mouse showing characteristic lamellar-lipid profiles. Arrows in D through F indicate lamellae. Cells in D and E are adrenocortical cells. Cell in F is a mesenchymal cell or an adrenocortical precursor. Scale bars: A and B, 100um; inset, 400um; C, 10um; D-F, 200nm.

Copyright

This image is from Faust PL, J Cell Biol 1997 Dec 1;139(5):1293-305, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:44975

Associated Alleles

Symbol	Name
Pex2^tm1Plf	peroxisomal biogenesis factor 2; targeted mutation 1, Phyllis L Faust

Associated Genotypes

Allelic Composition	Genetic Background
Pex2^tm1Plf/Pex2^tm1Plf	involves: 129S1/Sv * 129X1/SvJ * C57BL/6