Phenotype Image Detail

Image

Caption

A: Litter of newborn mice with three Pex2^tm1Plf/Pex2^tm1Plf mice (top row) and four control mice (bottom row). Note the absence of milk in the stomach and variable size in the mutant mice. Abnormal facies are not evident in the mutant mice. B-H: Alcian blue (cartilage) and alizarin red (bone) staining of newborn mouse calvarium. The weight of each mouse is shown. B: Typical appearance of the calvarium in control mice (70%). f, frontal bone; p, parietal bone; ip, interparietal bone. C: Control mouse with slightly open "anterior fontanelle: but relatively normal bone density (19%). D: Runted, control mouse showing slight enlargement of fontanelle space and reduced bone density in medial frontal and interparietal bone. E-H: Mutant mice, demonstarting the correlation of increasing severity in reduction of bone density in frontal and interparietal bones and enlargement of fontanelle spaces with decreasing size of the mouse. Scale bars: 1cm.

Copyright

This image is from Faust PL, J Cell Biol 1997 Dec 1;139(5):1293-305, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:44975

Associated Alleles

Symbol	Name
Pex2^tm1Plf	peroxisomal biogenesis factor 2; targeted mutation 1, Phyllis L Faust

Associated Genotypes

Allelic Composition	Genetic Background
Pex2^tm1Plf/Pex2^tm1Plf	involves: 129S1/Sv * 129X1/SvJ * C57BL/6