Phenotype Image Detail

Image

Caption

The apical surfaces of normal (a,c and e) and Upk3a^tm1Tsun/Upk3a^tm1Tsun (b,d and f) urothelia (of 2-3 month old mice) were examined by scanning electron micrograph. Note the highly rugged and folded surface of large ~100-150um diameter) normal umbrella cells (arrowheads mark the outline of one such cell in a) and the much smaller (15-25um) and smooth surfaced, mutant superficial cells. Also note the frequent desquamation of the superficial cells (b,*) and the much larger ureteral orifice (vesicoureteral junction, VJ; 120-150 vs. 40-60um diameter) of the mutant bladder. Scale bars: a and b, 25um; c and d. 5um; e and f, 50um.

Copyright

This image is from Hu P, J Cell Biol 2000 Nov 27;151(5):961-72, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:77653

Associated Alleles

Symbol	Name
Upk3a^tm1Tsun	uroplakin 3A; targeted mutation 1, Tung-Tien Sun

Associated Genotypes

Allelic Composition	Genetic Background
Upk3a^tm1Tsun/Upk3a^tm1Tsun	either: (involves: 129S/SvEv) or (involves: 129S/SvEv * Swiss Webster)