Phenotype Image Detail

Image

Caption

A: Calcein double labeling in 6 month old wild type and Lrp5^tm1Kry/Lrp5^tm1Kry mice. The distance between the two labels (double-headed arrows) represents the matrix apposition rate (MAR) which is decreased in mutant mice. As a result, the bone formation rate (BFR) is significantly lower in mutant mice. B: Decreased osteoblast number per bone area in the primary (left) and secondary (right) spongiosa of mutant mice compared with wild type. C: Delayed mineralization in primary mutant osteoblast cultures compared with wild type cultures at day 10 of mineralization. D: Normal tibial growth plate in 2 month old mutant mice (von Kossa stain). Asterisks indicate a statistically significant difference between two groups of mice (P<0.05). Error bars represent SD.

Copyright

This image is from Kato M, J Cell Biol 2002 Apr 15;157(2):303-14, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:75973

Associated Alleles

Symbol	Name
Lrp5^tm1Kry	low density lipoprotein receptor-related protein 5; targeted mutation 1, Gerard Karsenty

Associated Genotypes

Allelic Composition	Genetic Background
Lrp5^tm1Kry/Lrp5^tm1Kry	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)