Phenotype Image Detail

Image

Caption

Whole hearts and cardiac muscle sections. Hearts from 10 week old Des^tm1Cap/Des^tm1Cap (-/-, A) and wild type (WT, E) mice demonstrate extensive areas of degeneration and calcification throughout the myocardium of mutant mice. Sections from mutant mice (B and C) and corresponding areas in wild type (F and G) were stained with Masson's trichrome to reveal areas of interstitial fibrosis and degeneration. High magnification of cardiac myofibers taken from nonfibrotic regions of mutant myocardium (D) and wild type (H) myocardium stained with hematoxylin and eosin. Several of the fibers from the mutant myocardium appear to be disrupted and disintegrating. Bars: D and H, 5um; C and G, 10um.

Copyright

This image is from Milner DJ, J Cell Biol 1996 Sep;134(5):1255-70, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:35123

Associated Alleles

Symbol	Name
Des^tm1Cap	desmin; targeted mutation 1, Yassemi Capetanaki

Associated Genotypes

Allelic Composition	Genetic Background
Des^tm1Cap/Des^tm1Cap	involves: 129S7/SvEvBrd * C57BL/6