Phenotype Image Detail

Image

Caption

Tissue sections from 10 week old wild type (wt, A) and Des^tm1Cap/Des^tm1Cap (-/-. B-E) myocardium stained with hematoxylin and eosin (A,B and D) or VonKossa's stain (C and E). Wild type muscle shows no degeneration, but mutant myocardium shows extensive degeneration and fibrosis. The extent of degeneration is more severe in superficial sections of the myocardium (D and E) than in sections taken deeper within the myocardium (B and C). The brown precipitate formed in sections stained with VonKossa's (C and E) stain indicates the presence of calcium deposits. The degeneration of cardiac tissue increases with age. A heart removed from an 11 week old mutant mouse (F and G) shows extensive degeneration. Note the absence of calcium deposits in this heart. The degeneration is so severe that some areas of the myocardium appear transparent (arrowhead, F and G). The same heart (G) with the external scar tissue of the myocardium cut and pulled back to reveal damaged cardiac muscle. Bar A-E, 10um.

Copyright

This image is from Milner DJ, J Cell Biol 1996 Sep;134(5):1255-70, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:35123

Associated Alleles

Symbol	Name
Des^tm1Cap	desmin; targeted mutation 1, Yassemi Capetanaki

Associated Genotypes

Allelic Composition	Genetic Background
Des^tm1Cap/Des^tm1Cap	involves: 129S7/SvEvBrd * C57BL/6