Phenotype Image Detail

Image

Caption

Transmission electron microscopy of cardiac muscle from wild type (wt, A) shows aligned arrays of myofibrils terminating and inserting at intercalated discs (arrowhead). Myofibrils are interrupted occasionally by packed strands of mitochondria. A number of fibers from Des^tm1Cap/Des^tm1Cap myocardium (B) show disorganization and signs of damage. The myofibrils are disorganized and in some cases appear to have separated from intercalated discs (arrowhead). Note that the mitochondria are also highly disorganized, and many appear to be swollen. C: Higher magnification view of b. Bars: 1.0um.

Copyright

This image is from Milner DJ, J Cell Biol 1996 Sep;134(5):1255-70, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:35123

Associated Alleles

Symbol	Name
Des^tm1Cap	desmin; targeted mutation 1, Yassemi Capetanaki

Associated Genotypes

Allelic Composition	Genetic Background
Des^tm1Cap/Des^tm1Cap	involves: 129S7/SvEvBrd * C57BL/6