Phenotype Image Detail

Image

Caption

Transmission electron microscopy of skeletal muscle from 10 week old mice. Sections of myofibers from wild type diaphragm (wt, A) show well-formed myofibrils in register, and paired mitochondria arranged in an orderly fashion at the Z-lines between adjacent myofibrils. Corresponding sections from Des^tm1Cap/Des^tm1Cap (-/-) diaphragm show numerous areas with severely disrupted myofibrils (B and C). The star in B identifies the area magnified in C. The myofibrils are not in register, and are often separated by large areas of cytoplasm. Some myofibrils appear to be disintegrating. The mitochondria are also very disorganized. Bars: 1.0um.

Copyright

This image is from Milner DJ, J Cell Biol 1996 Sep;134(5):1255-70, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:35123

Associated Alleles

Symbol	Name
Des^tm1Cap	desmin; targeted mutation 1, Yassemi Capetanaki

Associated Genotypes

Allelic Composition	Genetic Background
Des^tm1Cap/Des^tm1Cap	involves: 129S7/SvEvBrd * C57BL/6