Phenotype Image Detail

Image

Caption

Defects in smooth muscle from mice lacking desmin. Sections of aorta from the outtrack (A and D) and thoracic (B and E) levels of Des^tm1Cap/Des^tm1Cap (-/-) and wild type (WT) mice. Note the clearing of cytoplasm around the myofiber nuclei (A) and hypoplasia of the smooth muscle layer (B) in aortic sections from mutant mice. Some areas between elastic fibers in the mutant aorta (B) appear devoid of cells. A loose organization of tissue can be seen in the circular (C) muscle layer of the stomach from mutant mice, as well as a slightly reduced thickness of the outer longitudinal (L) layer of muscle of the stomach when compared to wild type tissue (F). Bar: 10um.

Copyright

This image is from Milner DJ, J Cell Biol 1996 Sep;134(5):1255-70, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:35123

Associated Alleles

Symbol	Name
Des^tm1Cap	desmin; targeted mutation 1, Yassemi Capetanaki

Associated Genotypes

Allelic Composition	Genetic Background
Des^tm1Cap/Des^tm1Cap	involves: 129S7/SvEvBrd * C57BL/6