Phenotype Image Detail

Image

Caption

A: Cataract incidence of wild type, Bub3^tm1Jvd/Bub3⁺, Rae1^tm1Jvd/Rae1⁺ and Bub3^tm1Jvd/Bub3⁺ Rae1^tm1Jvd/Rae1⁺ mice as detected by the use of slit light after dilating the eyes. The asterisk indicates that the curve is statistically different from that of wild type mice using a log-rank test. B: Overt cataract detected in a 15 month old double heterozygous mouse. C: Cross section of a cataractous lens from a 15 month old double heterozygous mouse stained with hematoxylin and eosin. Note that the posterior portion of the eye has Morgagnian globules, whereas the inner portion has profound calcification. Bar, 1mm.

Copyright

This image is from Baker DJ, J Cell Biol 2006 Feb 13;172(4):529-40, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:105717

Associated Alleles

Symbol	Name
Bub3^tm1Jvd	BUB3 mitotic checkpoint protein; targeted mutation 1, Jan M A van Deursen
Rae1^tm1Jvd	ribonucleic acid export 1; targeted mutation 1, Jan M A van Deursen

Associated Genotypes

Allelic Composition	Genetic Background
Bub3^tm1Jvd/Bub3^+ Rae1^tm1Jvd/Rae1^+	Not Specified