Phenotype Image Detail

Image

Caption

A and B: Vasculature is present in wild type (Tgfb1^+/+, A) yolk sac (arrows) but is not identifiable in an E12.5 Tgfb1^tm1Jmu/Tgfb1^tm1Jmu (Tgfb1^RGE/RGE, B) embryo. C-E: Histologic appearance of wild type and mutant E12.5 yolk sacs. In the mutant yolk sacs, there is poor contact between endothelial and mesothelial layers and, in E, absence of blood cells. F: Langerhans cells (LCs) are absent in epidermis from back and ear of mutant mice. G: LCs are less abundant in back epidermis (arrows) and absent in ear epidermis of Itgb6^tm1Des/Itgb6^tm1Des (Itgb6^-/-) mice. H: Compared with wild type mice, Itgb6^tm1Des/Itgb6^tm1Des mice have fewer LCs in back epidermis. P=0.001. Error bars indicate means +/-SEM.

Copyright

This image is from Yang Z, J Cell Biol 2007 Mar 12;176(6):787-93, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:120085

Associated Alleles

Symbol	Name
Itgb6^tm1Des	integrin beta 6; targeted mutation 1, Dean Sheppard
Tgfb1^tm1Jmu	transforming growth factor, beta 1; targeted mutation 1, John Munger

Associated Genotypes

Allelic Composition	Genetic Background
Tgfb1^tm1Jmu/Tgfb1^tm1Jmu	involves: 129S6/SvEvTac * C57BL/6
Itgb6^tm1Des/Itgb6^tm1Des	involves: 129S4/SvJae