Phenotype Image Detail

Image

Caption

Electron micrographs of parietal cells. A: Parietal cell from a wild type mouse, with well developed sectetory canaliculus (c), nucleus (N) and many mitochondria. B: In the Atp4a^tm1Ges/Atp4a^tm1Ges parietal cell, canaliculi were dilated, and microvilli of the canaliculus (arrowheads) were less abundant, shorter, and more densely stained than in wild type cells. Mutant parietal cells contained a few rounded vesicles (arrows) rather than numerous tubulovesicles and accumulated glycogen (g). C: Mutant parietal cells often contained large mitochondria with concentric cristae. Scale bars: A and B, 5um; C, 1um.

Copyright

This image is from Spicer Z, J Biol Chem 2000 Jul 14;275(28):21555-65 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:63470

Associated Alleles

Symbol	Name
Atp4a^tm1Ges	ATPase, H+/K+ exchanging, gastric, alpha polypeptide; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Atp4a^tm1Ges/Atp4a^tm1Ges	involves: 129X1/SvJ * Black Swiss