Phenotype Image Detail

Image

Caption

PAS/Alcian blue stained stomach sections from wild type and Atp4a^tm1Ges/Atp4a^tm1Ges gastric glands. Paraffin embedded sections from adult mouse stomachs were stained with periodic acid-Schiff (PAS) and Alcian blue to analyze carbohydrate moieties. A: Mucous cells in the apex of wild type oxyntic glands stained bright red (arrows), indicating the presence of neutral polysaccharides. B: Mucous cells in the apex of Atp4a^tm1Ges/Atp4a^tm1Ges oxyntic glands exhibited the normal red staining (arrows), but mucous cells surrounding cystically dilated regions often stained purple (arrowheads), indicating the presence of both neutral and acidic polysaccharides, C: In addition to cells staining red or purple, a small cyst at the base of the mutant gastric gland contained cells that stained blue (arrows), indicating the presence of acidic polysaccharides and the absence of neutral polysaccharides. Scale bar: A and B, 50um; C, 20um.

Copyright

This image is from Spicer Z, J Biol Chem 2000 Jul 14;275(28):21555-65 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:63470

Associated Alleles

Symbol	Name
Atp4a^tm1Ges	ATPase, H+/K+ exchanging, gastric, alpha polypeptide; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Atp4a^tm1Ges/Atp4a^tm1Ges	involves: 129X1/SvJ * Black Swiss